Scientists find a genetic link between insomnia and depression

Depression and   sleep disorders related   – this conclusion was made by researchers from   USA. They found molecular genetic pathways that are involved in   the development of both major depressive disorder and   insomnia as well   also identified one specific gene, which acts as a link between them. Read more about   the work says in   article published at   Science Advances .

Behavioral disturbances and sleep disorders are often combined with each other.   a friend. For example, major depressive disorder ( major depressive disorder , MDD) is almost always accompanied by problems with   sleep and   shift in   his rhythms as well   total sleep deprivation can be used in   as a temporary antidepressant.

AT   Some large-scale transcriptome assays have already found many molecular correlates that are common to sleep, emotional or depression. AT   the number of traits studied even included the regulation of circadian rhythms. None   however, it remained unclear which gene aggregates are involved here and   how in   depending on   they are coordinated by the work of numerous neural networks located in   different parts of the brain and   causing behavior.

To find gene networks related to   different behavioral functions, researchers led by Martha Vitaters ( Martha Vitaterna ), professors of the Center for Sleep Biology and   circadian rhythms in   Northwestern University, investigated 20   categories of phenotypes that included 283   cognitive, emotional and   doubtful characteristics. Their   singled out in   populations of   129 mice with   deprivation of sleep and   compared with   genetic groups from   2458 markers in   four areas of the brain, key to controlling sleep and   emotions (frontal cortex, hippocampus , thalamus and  hypothalamus).

Thanks to this, researchers were able to identify the network of transcriptomes responsible for   one or another type of function, including the nature of sleep, and   they thereby created the basis for studying how these functional networks of genes can change in a major depressive disorder.Multiple connections between sleep and   emotional manifestations showed up like on   single gene level and   on   level of the whole gene network.

In addition, scientists used publicly available transcriptomic data sets obtained from   people with   major depressive disorder, and   compared them   with   what you found in   mouse models of deprivation. It turned out that some   those   same gene patterns, specifically for the cortex, are involved and   with M DD   in people and   with complete sleep deprivation   mice. Moreover, the deprivation of sleep and   depression influenced   gene expression in   these networks are the opposite, potentially explaining the antidepressant effects of insomnia.

Moreover, researchers have identified a particular gene network of avisyaschih from   neuron activity   – regulators of circadian rhythm and   production of cyclic adenosine monophosphates ( cAMP ). As it turned out, they are the most sensitive and   react as early as possible to   failures, thereby providing a mechanical basis, confirming the relationship of sleep and   depressed. Of   their   numbers even managed to single out one   – Arc gene , which directly controls the activity of this network (launches   her) and   becomes the “missing link” that binds the emotional sphere and  sleep.

Scientists believe that their   The findings complement the understanding of the molecular bases underlying   basis of the interaction of doubtful regulation and   affective disorders, and   hope that   Based on this, it will be possible to develop more effective means of combating   depressed and  sleep disorders.

Meanwhile not   so long ago, researchers found a specific type of neuron responsible for   sleep as well   also determined that depression can adversely affect   the integrity of the white matter of the brain.

Eating disorders due to sleep problems

Eating disorders due to sleep problems are characterized by a violation of the diet (food at night).

Although it is not as common as sleepwalking, nocturnal eating disorders may occur during a sleepwalking episode. People suffering from this disorder eat without waking up. They can go into the kitchen and start cooking (later they may not even remember). If attacks of this kind of disorder occur quite often, then a person may find weight gain or increased susceptibility to the development of type 2 diabetes.

There is a similar disorder called night eating syndrome. Those suffering from this syndrome eat at night, being fully conscious; perhaps due to inability to fall asleep without first having eaten anything.

Symptoms of nocturnal eating behavior include the following and can last more than two months:

  • Bad appetite or lack of it at breakfast.
  • Eating more food after dinner than at dinner.
  • Eating half a day’s food after dinner.
  • Frequent awakening due to the need to eat something.

An eating disorder due to sleep problems and nocturnal eating behavior syndrome are different in that in the second, people eat while conscious. However, disorders have much in common, as they are associated with sleep problems and eating disorders. Both the first and second can affect the human diet, cause shame and guilt, depression and excess weight.

Who is predisposed to eating disorder?

Both men and women are equally predisposed to this disorder, but it is still more common in women. 10% – 15% of people with eating disorders suffer from eating disorders due to sleep problems. Most of these people are dieting during the daytime, as a result of which they are constantly hungry and more vulnerable to the temptation to eat (control is dulled by sleep). In some cases, an eating disorder is associated with alcoholism, drug abuse and other sleep disorders.

How is an eating disorder treated?

Treatment begins with a clinical examination. May be needed   hospitalization in a hospital where doctors will monitor brain activity during sleep throughout the night. In some cases, medications can help. However, care should be taken to avoid sleeping pills, as it can increase disorientation in time and space, which can even lead to injury. Additional treatments include stress and anxiety. Examples of such methods include stress management courses, self-confidence training, counseling, and alcohol and caffeine restriction.




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